AZD8330 (AZD-8330, ARRY-424704, ARRY-704, ARRY424704, ARRY704)是新型的、可口服的、非ATP竞争性的MEK1/2抑制剂，IC₅₀为7 nM，通过抑制MEK1/2有效抑制多种肿瘤细胞增殖，具有潜在的抗癌活性。

参考文献

[1] Wallace EM, et al. Progress towards therapeutic small molecule MEK inhibitors for use in cancer therapy. Curr Top Med Chem. 2005;5(2):215-29.

[2] Baranski Z, et al. MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation. Genes Cancer. 2015 Nov;6(11-12):503-12.

[3] Cohen RB, et al. A phase I dose-finding, safety and tolerability study of AZD8330 in patients with advanced malignancies. Eur J Cancer. 2013 May;49(7):1521-9.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。