AZ 628 (AZ628)是Raf激酶抑制剂，通过结合Raf激酶的ATP结合位点，抑制CRAF的活化，作用于野生型B-Raf的IC₅₀值为105 nM，Raf-B V600E为34 nM，野生型c-Raf-1为29 nM。AZ 628具有抗肿瘤活性，能够诱导细胞凋亡。

参考文献

[1] Khazak V, et al. Selective Raf inhibition in cancer therapy. Expert Opin Ther Targets. 2007 Dec;11(12):1587-609.

[2] Strassburger M, et al. Anti-inflammatory treatment with the p38 mitogen-activated protein kinase inhibitor SB239063 is neuroprotective, decreases the number of activated microglia and facilitates neurogenesis in oxygen-glucose-deprived hippocampal slice cultures. Eur J Pharmacol. 2008 Sep 11;592(1-3):55-61.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。