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Conductive coordination nanozyme prodrugs precisely trigger pyroptosis, cuproptosis and ferroptosis for in situ cancer vaccination

Journal:Signal Transduction and Targeted Therapy|DOI:10.1038/s41392-026-02607-6|IF:81.2|Published:2026

Thromboxane receptor activation in dendritic cells mitigates sepsis by suppressing S100a8/a9-mediated neutrophil recruitment

Journal:Signal Transduction and Targeted Therapy|DOI:10.1038/s41392-026-02592-w|IF:81.2|Published:2026

Unleashing the potential of bimetallic nanobomb-mediated STING pathway to enhance bispecific T-cell engager against colorectal cancer photo-immunotherapy

Journal:Signal Transduction and Targeted Therapy|DOI:10.1038/s41392-026-02596-6|IF:81.2|Published:2026

A biosafe mouse model for SARS-CoV-2 infection that more realistically simulates COVID-19 symptoms

Journal:Signal Transduction and Targeted Therapy|DOI:10.1038/s41392-026-02640-5|IF:81.2|Published:2026

Investigating the effects and underlying mechanisms of glycosylation sites on the immunogenicity of COVID-19 vaccines

Journal:Signal Transduction and Targeted Therapy|DOI:10.1038/s41392-026-02751-z|IF:81.2|Published:2026

Disrupting SOX2 self-association and condensate formation to overcome chemotherapeutic drug resistance in lung squamous cell carcinoma

Journal:Signal Transduction and Targeted Therapy|DOI:10.1038/s41392-026-02696-3|IF:81.2|Published:2026

BMX inhibition overcomes small cell lung cancer chemoresistance by stabilizing E2F1 via ERK1/2-Cyclin D1/CDK4/6 axis

Journal:Signal Transduction and Targeted Therapy|DOI:10.1038/s41392-026-02644-1|IF:81.2|Published:2026

Molecular mechanism of cholesterol-dependent membrane fusion in SARS-CoV-2 entry

Journal:Signal Transduction and Targeted Therapy|DOI:10.1038/s41392-026-02573-z|IF:81.2|Published:2026

Targeting ZMIZ1 induces differentiation in acute myeloid leukemia via chromatin remodeling

Journal:Signal Transduction and Targeted Therapy|DOI:10.1038/s41392-026-02766-6|IF:81.2|Published:2026

VCPIP1 drives diabetic cardiomyopathy by deubiquitinating AMPKγ1 and preventing AMPKα-γ subunit assembly in cardiomyocytes

Journal:Signal Transduction and Targeted Therapy|DOI:10.1038/s41392-026-02701-9|IF:81.2|Published:2026

Dual epitope anti-LILRB4 synthetic T-cell receptor and antigen receptor (STAR)-T-cell therapy for relapsed/refractory acute myeloid leukemia

Journal:Signal Transduction and Targeted Therapy|DOI:10.1038/s41392-026-02765-7|IF:81.2|Published:2026

Spatiotemporally programmed nanomedicine engineering to resolve conflicting immunosignals in triple-negative breast cancer

Journal:Signal Transduction and Targeted Therapy|DOI:10.1038/s41392-026-02685-6|IF:81.2|Published:2026

Molecular mechanism of allosteric modulation of opioid receptors

Journal:Signal Transduction and Targeted Therapy|DOI:10.1038/s41392-026-02759-5|IF:81.2|Published:2026

Lenvatinib enhances the response of biliary tract cancer to anti-HER2 therapy

Journal:Signal Transduction and Targeted Therapy|DOI:10.1038/s41392-026-02775-5|IF:81.2|Published:2026

RYK is a GPNMB receptor that drives MASH

Journal:NATURE|DOI:10.1038/s41586-026-10160-z|IF:56.1|Published:2026

A broadly protective antibody targeting gammaherpesvirus gB

Journal:NATURE|DOI:10.1038/s41586-026-10192-5|IF:56.1|Published:2026

Engineered immunosuppressive dendritic cells protect against cardiac remodelling

Journal:NATURE|DOI:10.1038/s41586-026-10346-5|IF:56.1|Published:2026

De novo design of GPCR exoframe modulators

Journal:NATURE|DOI:10.1038/s41586-025-09957-1|IF:56.1|Published:2026

CHPO coordinates chilling recovery and nitrogen use in rice

Journal:NATURE|DOI:10.1038/s41586-026-10682-6|IF:56.1|Published:2026

Single-cell screens identify ADAM12 as a fibroblast checkpoint impeding anti-tumor immunity

Journal:CANCER CELL|DOI:10.1016/j.ccell.2025.12.018|IF:56.1|Published:2026