LY2157299是高效特异性的TGF-β receptor I (TGF-βRI) 抑制剂（TβRI拮抗剂），其IC50值为56 nM。LY2157299能有效抑制TGFβ受体信号，可用于评估对肝癌的抗肿瘤活性。LY2157299可抑制HUVEC细胞中TGFβ诱导的Smad2的磷酸化，抑制肿瘤细胞增殖，具有显著的抗肿瘤活性。

参考文献

[1]. Dituri F, et al. Differential inhibition of the TGF-β signaling pathway in HCC cells using the small molecule inhibitor LY2157299 and the D10 monoclonal antibody against TGF-β receptor type II. PLOS One, 2013, 8(6): e67109.

[2]. Bueno L, et al. Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-β kinase antagonist, in mice. European journal of cancer, 2008, 44(1): 142-150.

冰袋运输。粉末直接保存于-20℃，有效期2年。溶于DMSO。建议分装后-20℃避光保存，避免反复冻融。