LY364947(HTS 466284) TGFβR-I抑制剂|CAS 396129-53-6（53030ES）

_{LY364947 (LY-364947, HTS 466284, HTS466284)是一种二杂芳基取代的吡唑类化合物，是有效的、ATP竞争性转化生长因子β I型受体激酶(TGFβR-I)抑制剂(IC50: 59 nM)，高于对TGFβR-II的选择性。}

参考文献

1.Li HY, et al. Dihydropyrrolopyrazole transforming growth factor-beta type I receptor kinase domain inhibitors: a novel benzimidazole series with selectivity versus transforming growth factor-beta type II receptor kinase and mixed lineage kinase-7. J Med Chem. 2006;49(6):2138-2142.

2.Peng SB, et al. Kinetic characterization of novel pyrazole TGF-beta receptor I kinase inhibitors and their blockade of the epithelial-mesenchymal transition. Biochemistry, 2005;44(7):2293-2304.

3.Oka M, et al. Inhibition of endogenous TGF-beta signaling enhances lymphangiogenesis. Blood, 2008;111(9):4571-4579.

4.Naka K, et al. TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. Nature, 2010;463(7281):676-680.

冰袋运输。粉末直接保存于-20℃，有效期2年。建议分装后-20℃避光保存，避免反复冻融。