SB-590885(SB590885) B-Raf抑制剂|CAS 405554-55-4（53596ES）

SB-590885 (SB590885)是ATP竞争性的B-Raf选择性抑制剂，K_i值为0.16 nM，具有潜在抗癌活性。

参考文献

1.King AJ, et al. Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. Cancer Res, 2006, 66(23), 11100-11105.

2.Takle AK, et al. The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett, 2006, 16(2), 378-381.

3.Smalley KS, et al. Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas. Mol Cancer Ther, 2008, 7(9), 2876-2883.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。