AICAR phosphate (Acadesine phosphate, AICA Riboside phosphate)，又称AICAR磷酸盐或阿卡地新磷酸。AICAR是一种可透过细胞膜的AMPK激活剂，通过模拟AMP刺激AMPK和AMPKK，但不影响ATP、ADP和AMP的水平。AICAR通过激活AMPK调节非胰岛素依赖性的糖代谢，还可以抑制自噬和炎症。

参考文献

1.Nakamaru K, et al. AICAR, an activator of AMP-activated protein kinase, down-regulates the IR expression in HepG2 cells. Biochem Biophys Res Commun. 2005 Mar 11;328(2):449-54.

2.Campàs C, et al. Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes. Blood. 2003 May 1;101(9):3674-80.

3.Drake JC, et al. AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1546-54.

4.Ajaybabu V Pobbati, et al. A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy. Theranostics. 2020 Feb 18;10(8):3622-3635.

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