SRI-011381(SRI011381) TGF-β信号通路激活剂|CAS 1629138-41-5（53562ES）

SRI-011381 (SRI011381)是可口服的TGF-β信号通路选择性激动剂，有神经保护活性，可用来治疗阿尔茨海默病。TGF-β信号在早期胚胎发育与组织器官形成、免疫调节、组织修复与成体稳态平衡中发挥重要作用。

参考文献

1.Jingyin Han, et al. The Improvement Effect of Sodium Ferulate on the Formation of Pulmonary Fibrosis in Silicosis Mice Through the Neutrophil Alkaline Phosphatase 3 (NALP3)/Transforming Growth Factor-β1 (TGF-β1)/α-Smooth Muscle Actin (α-SMA) Pathway. Med Sci Monit. 2021 Jun 15;27:e927978.

2.Qian Wu, et al. Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling. Theranostics. 2021 Jul 25;11(17):8480-8499.

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