SB-431542 (SB431542; SB 431542)是Src家族激酶抑制剂，是TGF-β信号通路抑制剂，也是强有效的ALK5抑制剂（其IC50值为94 nM），可抑制TGF-β介导的SMAD蛋白活化、细胞增殖和细胞运动等，可有效抑制由生长因子β1诱导的细胞在原发和继发性癌细胞中的迁移和侵袭的进程。

参考文献

[1] Laping NJ, et al. Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542. Mol Pharmacol. 2002 Jul;62(1):58-64.

[2] Tanaka H, et al. Transforming growth factor β signaling inhibitor, SB-431542, induces maturation of dendritic cells and enhances anti-tumor activity. Oncol Rep. 2010 Dec;24(6):1637-43.

[3] Matsuyama S, et al. SB-431542 inhibits transforming growth factor-beta-induced proliferation of human osteosarcoma cells. Cancer Res, 2003, 63(22), 7791-7798.

[4] Lee AJ, et al. Sustained Delivery of SB-431542, a Type I Transforming Growth Factor Beta-1 Receptor Inhibitor, to Prevent Arthrofibrosis. Tissue Eng Part A. 2021 May 12.

冰袋运输。粉末直接保存于-25~-15℃，有效期2年。建议避光干燥保存，避免反复冻融。