SB 216763 (SB-216763, SB216763) 是一种强效的、细胞可渗透的、具有ATP竞争性的GSK-3抑制剂，同时抑制GSK-3α和GSK-3β，其IC₅₀值均为34.3 nM。SB 216763可激活细胞自噬，防止PI3-激酶途径诱导的神经细胞死亡：SB-216763可以使中枢和外周神经系统的神经元免受PI3K途径介导的细胞死亡。它还可以在大鼠模型中防止心肌缺血，表现出心脏保护作用，被广泛应用于各种动物模型来研究GSK-3的作用。

参考文献

[1]. Zhong JQ, Xie YK, et al. [Effects of glycogen synthase kinase 3β overexpression in rat and glycogen synthase kinase 3β inhibitor SB-216763 on proliferation of hepatic oval cells]. Zhonghua Wai Ke Za Zhi. 2012 Nov;50(11):1003-6. Chinese. PMID: 23302485.

[2]. Zhang YD, et al. SB-216763, a GSK-3β inhibitor, protects against aldosterone-induced cardiac, and renal injury by activating autophagy. J Cell Biochem. 2018 Jul;119(7):5934-5943.

[3]. Wickens RH, et al. Inhibition of glycogen synthase kinase-3 by SB 216763 affects acquisition at lower doses than expression of amphetamine-conditioned place preference in rats. Behav Pharmacol. 2017 Jun;28(4):262-271.

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