PI-828 (PI828, PI 828) 是细胞渗透性的、PI3K和CK2的双重抑制剂，对p110β，p110α，p110δ和p110γ等也有抑制作用，对应的IC₅₀值分别为0.098、0.173、0.227和1.967 μM，对CK2和CK2α2的IC₅₀分别为149 nM和1127 nM。PI-828可固定在含环氧基的固体表面上并能与非PI3K细胞蛋白发生反应。

参考文献

[1]. Kulkarni AA, Roy B, et al. Supramolecular nanoparticles that target phosphoinositide-3-kinase overcome insulin resistance and exert pronounced antitumor efficacy. Cancer Res. 2013 Dec 1;73(23):6987-97.

[2]. Nichols NL, et al. Mechanisms of Enhanced Phrenic Long-Term Facilitation in SOD1G93A Rats. J Neurosci. 2017 Jun 14;37(24):5834-5845.

[3]. Ho MX, et al. Icariin, but Not Genistein, Exerts Osteogenic and Anti-apoptotic Effects in Osteoblastic Cells by Selective Activation of Non-genomic ERα Signaling. Front Pharmacol. 2018 May 11; 9:474.

冰袋运输。粉末直接保存于-20℃，有效期2年。建议分装后-20℃避光保存，避免反复冻融。