AT-406又称为SM-406、ARRY-334543，是一种有效的、口服生物活性的拟Smac的凋亡蛋白抑制剂（IAP）拮抗剂，与XIAP-BIR3、cIAP1-BIR3和cIAP2-BIR3结合，Ki分别为66.4 nM、1.9 nM和5.1 nM。AT-406可抑制多种癌细胞生长，并诱导小鼠体内移植瘤凋亡。

目前，AT-406已用于临床Phase 1研究阶段。

【该产品仅用于科研实验，不能用于人体】

参考文献

[1] Cai Q, et al. A Potent and Orally Active Antagonist (SM-406/AT-406) of Multiple Inhibitor of Apoptosis Proteins (IAPs) in Clinical Development for Cancer Treatment. Journal of Medicinal Chemistry 54(8): 2714-2726 (2011).

[2] Brunckhorst MK, et al. AT-406, an orally active antagonist of multiple inhibitor of apoptosis proteins, inhibits progression of human ovarian cancer. Cancer Biol Ther. 13(9):804-811 (2012).

[3] Miura K, et al. Inhibitor of apoptosis protein family as diagnostic markers and therapeutic targets of colorectal cancer. Surg Today. 41(2):175-182 (2011).

冰袋运输。粉末直接保存于-20 ºC，有效期2年。易溶于DMSO和乙醇。建议分装后-20ºC避光保存，避免反复冻存，至少可存放6个月。