C8-Ceramide N-辛酰基-D-神经鞘氨醇(又名N-Octanoyl-D-erythro-sphingosine)C8神经酰胺具有抗肿瘤抗增殖功能,抑制肝细胞癌,可增加内源性ROS水平,诱导强烈的CD8+和CD4+T细胞免疫反应,可作为一种化疗剂。
参考文献
[1]. Rebeca López-Marure , et al. Ceramide promotes the death of human cervical tumor cells in the absence of biochemical and morphological markers of apoptosis. Biochem Biophys Res Commun. 2002 May 10;293(3):1028-36.
[2]. Yuli C. Chang, et al. Exogenous C8-Ceramide Induces Apoptosis by Overproduction of ROS and the Switch of Superoxide Dismutases SOD1 to SOD2 in Human Lung Cancer Cells. Int J Mol Sci. 2018 Oct; 19(10): 3010.
[3]. Curtis J. Pritzl, et al. A ceramide analogue stimulates dendritic cells to promote T cell responses upon virus infections. J Immunol. 2015 May 1; 194(9): 4339-4349.
冰袋运输。粉末直接保存于-20℃,有效期3年。建议分装后-20℃干燥保存,避免反复冻融。