Paclitaxel (NSC 125973, NSC125973, PTX, Taxol, Abraxane)，又称紫杉醇，是从天然植物红豆杉属树皮中提取的单体双萜类化合物，光谱的天然抗肿瘤药，可稳定微管蛋白聚合（IC₅₀为0.1 pM），抑制细胞有丝分裂，诱导细胞凋亡。Paclitaxel是有丝分裂的抑制剂。

参考文献

1.Choi YH, et al. Paclitaxel-induced growth arrest and apoptosis is associated with the upregulation of the Cdk inhibitor, p21WAF1/CIP1, in human breast cancer cells. Oncol Rep. 2012 Dec;28(6):2163-9.

2.Chang J, et al. Estrogen receptor α attenuates therapeutic efficacy of paclitaxel on breast xenograft tumors. Breast Cancer Res Treat. 2012 Aug;134(3):969-80.

3.Li Q, et al. Low doses of paclitaxel enhance liver metastasis of breast cancer cells in the mouse model. FEBS J. 2016 Aug;283(15):2836-52.

4.Yilmaz E, et al. Sensory neuron subpopulation-specific dysregulation of intracellular calcium in a rat model of chemotherapy-induced peripheral neuropathy. Neuroscience. 2015 Aug 6;300:210-8.

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