Y-27632 dihydrochloride（又名Y27632 dihydrochloride, Y 27632 dihydrochloride, Y27632 2HCl）是一种高效、选择性、ATP竞争性ROCK抑制剂，作用于ROCK1 (p160ROCK) (Ki = 140 nM)和ROCK-II (IC50 = 800 nM)，并抑制PRK2活性。Y-27632作用于人胚胎干细胞(hES)明显降低细胞分离诱导的细胞凋亡，提高克隆形成效率。Y-27632还可以促进体外培养的人角膜上皮细胞增殖。

参考文献

[1]. Uehata M, et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389(6654): 990-994 (1997).

[2]. Sun CC, et al. Y-27632, a ROCK Inhibitor, Promoted Limbal Epithelial Cell Proliferation and Corneal Wound Healing. PLoS ONE 10(12): e0144571 (2015).

冰袋运输。粉末直接保存于-20℃，有效期2年。建议分装后-20℃干燥保存，避免反复冻融。