Ciliobrevin A (HPI-4, HPI4, HPI 4, Hedgehog Pathway Inhibitor 4)是Hedgehog (Hh)信号通路抑制剂，抑制Shh诱导的Hh信号通路的激活，其IC₅₀值为7 μM。Ciliobrevin下调信号分子Smo水平，抑制细胞质ATP酶动力蛋白依赖的微管滑动和ATP酶活性，抑制纤毛生成。

参考文献

[1].  Xiang W, et al. Hedgehog pathway inhibitor-4 suppresses malignant properties of chondrosarcoma cells by disturbing tumor ciliogenesis. Oncol Rep. 2014 Oct;32(4):1622-30.

[2]. Jung IH, et al. Aberrant Hedgehog ligands induce progressive pancreatic fibrosis by paracrine activation of myofibroblasts and ductular cells in transgenic zebrafish. PLoS One. 2011;6(12): e27941.

冰袋运输。粉末直接保存于-20℃，有效期2年。建议分装后-20℃干燥保存，避免反复冻融。