Abstract

Esophageal cancer is a lethal disease that frequently occurs in developing countries, the incidence of which could be declined by drinking EGCG-enriched drinks or food.SERPINB2, whose complex functions and regulations are not yet fully understood, are induced by multiple inflammatory molecules and anti-tumor agents. Here, we identify 2444 EGCG-regulated genes in esophageal cancer cells, includingSERPINB2. EGCG treatment recruits NF-κB at the promoter and enhancers ofSERPINB2and activates gene transcription, which is repressed by NF-κB knockdown or inhibition. Loss ofSERPINB2leads to a faster migration rate and less expression of Caspase-3 in cancer cells. Our study demonstrates thatSERPINB2is a new tumor-suppressor gene involved in cell movement and apoptosis and could be a therapeutic target for esophageal cancer.Keywords:esophageal cancer;EGCG;SERPINB2;apoptosis