[ 1 ]BMX inhibition overcomes small cell lung cancer chemoresistance by stabilizing E2F1 via ERK1/2-Cyclin D1/CDK4/6 axis

[ 2 ]VCPIP1 drives diabetic cardiomyopathy by deubiquitinating AMPKγ1 and preventing AMPKα-γ subunit assembly in cardiomyocytes

[ 3 ]NLR surveillance of pathogen interference with hormone receptors induces immunity

[ 4 ]Opioid-induced fragile-like regulatory T cells contribute to withdrawal

[ 5 ]Sensing endoplasmic reticulum redox state by ethylene receptors

[ 6 ]Efficient amyloid-β degradation in Alzheimer’s disease using SPYTACs

[ 7 ]Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1β-producing macrophages

[ 8 ]Mg2+ in drinking water boosts Salmonella infection risk by rewiring gut ecology and virulence

[ 9 ]Large-scale phage cultivation for commensal human gut bacteria

[ 10 ]Krüppel-like factor 2 programs early exhausted T cell states and restrains antiviral immunity

[ 11 ]A mitochondria-targeted nanoantioxidant restores alveolar bone homeostasis in periodontitis by quenching ROS and suppressing the cGAS-STING pathway

[ 12 ]Gut DNA virome enterotype dictates inflammation heterogeneity through tuning the phage-bacteria-sphingosine-intestine axis in Crohn's disease

[ 13 ]Engineered probiotics recruit CAR macrophages and establish immune memory to eradicate heterogeneous glioblastoma in mice

[ 14 ]THY1+ cancer stem cells drive metastasis through a pseudohypoxic state shaped by neutrophil-derived mitochondria

[ 15 ]Cell Membrane Vesicles Encapsulating Il24 mRNA With Enriched CD6 Display Exhibit Enhanced Targeted Antitumor Efficacy

[ 16 ]Immunoregulatory Nanofiber Patches with Locally Activated Delivery of ECM-Producing Drugs Improve Repair in an Intervertebral Disc Herniation Model

[ 17 ]Multifunctional Hydrophilic Selenium-Polyurea for Controlled Ion Release of Biodegradable Alloys and Immuno-osteogenic Synergistic Modulation

[ 18 ]KLF4 inhibits early neural differentiation of ESCs by coordinating specific 3D chromatin structure

[ 19 ]Immuno-Training Remodeled Vascular Microenvironment via Peptide-Functionalized Hydrogel Microspheres for Neural Repair

[ 20 ]Engineered human spinal cord-like tissues with dorsal and ventral neuronal progenitors for spinal cord injury repair in rats and monkeys

[ 21 ]Fabrication, bacteriostasis and osteointegration properties researches of the additively-manufactured porous tantalum scaffolds loading vancomycin

[ 22 ]A clinic-responder-derived defined microbial consortium enhances anti-PD-1 immunotherapy efficacy in mice

[ 23 ]NCX1 reverse mode promotes calcium-dependent Neutrophil Extracellular Trap formation and lung damage in chronic obstructive pulmonary disease

[ 24 ]Cross-species insights into placental evolution and diseases at the single-cell resolution

[ 25 ]Prefusion-stabilized Hantaan virus glycoprotein nucleic acid vaccine elicits potent neutralizing antibody responses via germinal center activation

[ 26 ]Photochemical nanomotors reverse anxiety- and depressive-related behaviors in rodents via spatiotemporal polarity dynamics tuning

[ 27 ]A non-enzymatic function of neuraminidase 1 restrains hepatic glucagon response in mice

[ 28 ]The PLAGL1-KLF4-IRX5 axis promotes the osteogenesis of periosteal progenitors during mandible regeneration

[ 29 ]The UFL1-AKT positive feedback loop promotes breast cancer progression by enhancing lipid synthesis

[ 30 ]Tissue-specific and sex-biased glycoproteomic landscape of Schistosoma mansoni

[ 31 ]Near-infrared light-driven nanomotors-based microneedles for the active therapy of bacterial infected acne

[ 32 ]Spatiotemporally controlled restoration of GAS6 signaling via mRNA therapy promotes scarless healing in preclinical models

[ 33 ]Interpretable modality-aware mapping of gene regulation in single-cell multiomics with scMAGCA

[ 34 ]Deep learning-assisted discovery of a potent and cell-active inhibitor of RNA N6-methyladenosine recognition protein YTHDC2

[ 35 ]PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells

[ 36 ]SLIT3: a novel regulator of odontogenic differentiation through Akt/GSK3β/β-catenin signaling pathway

[ 37 ]MARCH2 suppresses odontoblast differentiation by polyubiquitinating PTPRD

[ 38 ]Proline/serine-rich coiled-coil 1 alleviates atherosclerosis via remodeling tryptophan metabolism mediated by Akkermansia muciniphila

[ 39 ]Intermittent Cobalt (II, III) Oxide Exposure Exacerbates Inflammatory Injury through Tumor Necrosis Factor-Alpha-Dependent Bone Marrow-Mediated Trained Immunity

[ 40 ]A plant virus-derived siRNA modulates wing dimorphism and fertility of vector insects to enhance virus spread

[ 41 ]Nafamostat mesilate improves sepsis outcomes by modulating complement and coagulation pathways

[ 42 ]Hepatocyte DDIT4 aggravates MASH progression through GPX4-mediated ferroptosis

[ 43 ]Modulation of MRSA virulence gene expression by the wall teichoic acid enzyme TarO

[ 44 ]Neuraminidase 1 promotes renal fibrosis development in male mice

[ 45 ]Inhibition of ALKBH5 attenuates I/R-induced renal injury in male mice by promoting Ccl28 m6A modification and increasing Treg recruitment

[ 46 ]Nucleus accumbens circuit disinhibits lateral hypothalamus glutamatergic neurons contributing to morphine withdrawal memory in male mice

[ 47 ]Stringent response ensures the timely adaptation of bacterial growth to nutrient downshift

[ 48 ]Meningeal Lymphatic System-Driven Nanodelivery Unlocks Ursolic Acid’s Pleiotropic Benefits To Optimize Multiple Sclerosis Treatment

[ 49 ]Single-Cell Sequencing Analysis-Driven Nanomedicine Design for Mimicking Endogenous Immune Repair in Myocardial Infarction

[ 50 ]In Situ Redox-Omics Decoding of Nanoparticle–Protein Corona Interactions Drives the Mitochondrial Metabolic-Immunological Mechanism in Microglia

[ 51 ]A pair of readers of bivalent chromatin mediate formation of Polycomb-based “memory of cold” in plants

[ 52 ]Glycolysis drives STING signaling to facilitate dendritic cell antitumor function

[ 53 ]Chemoproteomic profiling reveals histone H4 dopaminylation inhibiting cell growth

[ 54 ]Treg-γδ T cell axis determines sexual dimorphism in hepatocarcinogenesis

[ 55 ]Vacancy defect-induced electron homing breaks phosphodiester bonds for RNA depletion-driven cancer therapy

[ 56 ]Maternal gut microbiota mediates prenatal stress-induced fetal blood‒brain barrier dysfunction

[ 57 ]Bacteroides-associated NAD⁺ depletion correlates with exacerbated radiation-induced colorectal injury and impaired mucosal proliferative capacity

[ 58 ]Bacillus-functionalized sewage sludge biochar boosts cabbage growth through improved nitrogen assimilation

[ 59 ]A Human-Specific De Novo Gene Promotes Cortical Expansion and Folding

[ 60 ]A core–shell microneedle platform for the spatiotemporal codelivery of dual-agent therapeutics precisely orchestrates diabetic wound healing

[ 61 ]Molecular basis of plant DCL4 action that outcompetes DCL2

[ 62 ]Leocarpinolide B alleviates epithelial tubular mitochondrial dysfunction via macrophage exosomal miR-204-5p/TFAM axis in AKI-CKD transition

[ 63 ]An integrated green control strategy for plant viral co-infections: from multivalent vaccine construction to synergistically modified nanodelivery systems

[ 64 ]Coptis chinensis extracellular vesicles loaded with CA1-siRNA promote endothelial repair and stent restenosis therapy by regulating the PADI2 and NF-κB pathway

[ 65 ]Nanobodies targeting the Epstein-Barr virus EBNA1 DNA binding domain inhibit tumor growth

[ 66 ]Microneedle-delivered ROS-adaptive asiatic acid nanoparticles promote scarless repair via remodeling the pathological microenvironment

[ 67 ]Protocatechualdehyde-functionalized BMSC-derived exosomes orchestrate calcium signaling in the immunoinflammatory microenvironment to promote periodontal regeneration

[ 68 ]BACH1 deficiency prevents neointima formation and maintains the differentiated phenotype of vascular smooth muscle cells by regulating chromatin accessibility

[ 69 ]A novel active transposon creates allelic variation through altered translation rate to influence protein abundance

[ 70 ]The deubiquitinating enzyme 13 retards non-alcoholic steatohepatitis via blocking inactive rhomboid protein 2-dependent pathway

[ 71 ]Small-molecule inhibition of the deadenylase CNOT6L as a strategy of obesity treatment

[ 72 ]Targeting eIF5A combats breast cancer progression by ClpP-dependent mitochondrial oxidative stress

[ 73 ]Holistic bone developing microenvironment engineered apoptotic extracellular vesicles recapitulate multidimensional developmental signatures in adult and senile bone repair

[ 74 ]A HHEX/IKKα positive feedback loop promotes intestinal inflammation

[ 75 ]PBK-Loaded secretory autophagosomes drive radiotherapy-induced systemic adipose depletion via MAPK/ERK-PRKA/PKA-LIPE/HSL signaling: a therapeutic target for esophageal cancer cachexia

[ 76 ]Ectopic B lymphocyte follicles exacerbate ischemic brain damage via MIF-CD74/CXCR4 and interferon signaling

[ 77 ]Reduced glycoprotein hormone β-5 links male aging and testosterone decline to increased adiposity

[ 78 ]Bacillus coagulans XY2 ameliorates copper-induced toxicity by bioadsorption, gut microbiota and lipid metabolism regulation

[ 79 ]Characterizing the obesogenic and fatty liver-inducing effects of Acetyl tributyl citrate (ATBC) plasticizer using both in vivo and in vitro models

[ 80 ]Trained Memory of Uterine Macrophages Improves Subsequent Pregnancy Outcomes

[ 81 ]Targeting KDM3B Elicits Anti-tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

[ 82 ]RIPK3 Orchestrates Scar-Associated Macrophage Dysfunction to Drive Pulmonary Fibrosis

[ 83 ]Targeting UXS1-Dependent Glucuronate Detoxification Potentiates Metformin's Anti-Tumor Efficacy in Lung Adenocarcinoma

[ 84 ]PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4-Targeted Probe

[ 85 ]Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3β Dependent Ubiquitin-Mediated NRF2 Degradation

[ 86 ]A Non-Canonical Core Transcriptional Regulatory Circuit Orchestrates Chromatin Reprogramming to Drive Osimertinib Resistance in Non-Small Cell Lung Cancer

[ 87 ]Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1-Mediated M1 Macrophage Polarization in Sarcoidosis

[ 88 ]Combating VEGFA-siRNA-Induced Metabolic Reprogramming via Glucose Utilization Deprivation

[ 89 ]Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27-IKK Double Negative-Feedback

[ 90 ]Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

[ 91 ]SLC2A3-Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

[ 92 ]Disengaging the Engine: Histone Deacetylases 1 and 2-Mediated Acetylation of Hexokinase-2 Regulates Energy Metabolism in Microglia Following Intracerebral Hemorrhage

[ 93 ]SATB2 Mediates H3K9 Delactylation by Recruiting HDAC3 to Repress LCN2 and Inhibit Lung Tumor Growth and Metastasis

[ 94 ]Super-Enhancer-Driven SOX4/SMAD3 Mediate Membrane Remodeling by Regulating Phospholipid Metabolism to Accelerate Leukemia Progression

[ 95 ]ERM Inhibition Confers Ferroptosis Resistance through ROS-Induced NRF2 Signaling

[ 96 ]Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

[ 97 ]Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long-Term Fine Particulate Matter Exposure

[ 98 ]Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

[ 99 ]GRAMD1/ASTER-mediated cholesterol transport promotes Smoothened cholesterylation at the endoplasmic reticulum

[ 100 ]Dual-targeted microspheres reshape the metabolic-immune microenvironment to reverse post-embolization dilemmas in hepatocellular carcinoma