[ 1 ]A DNA/DMXAA/Metal–Organic Framework Activator of Innate Immunity for Boosting Anticancer Immunity

[ 2 ]Mechanoactive Nanocomposite Hydrogel to Accelerate Wound Repair in Movable Parts

[ 3 ]Pangenomic analysis of Chinese gastric cancer

[ 4 ]Copy number amplification of ENSA promotes the progression of triple-negative breast cancer via cholesterol biosynthesis

[ 5 ]circTNIK Promotes Carbon Nanotubes-Induced Lung Carcinogenesis via GRP78-Mediated Endoplasmic Reticulum Stress and Suppression of Type I Interferon Signaling

[ 6 ]LncRNA modulates Hippo-YAP signaling to reprogram iron metabolism

[ 7 ]Cell-fate transition and determination analysis of mouse male germ cells throughout development

[ 8 ]Heliangin acts as a covalent ligand of RPS2 that disrupts pre-rRNA metabolic processes in NPM1-mutated acute myeloid leukemia

[ 9 ]DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling-Mediated Anti-tumor Immunity

[ 10 ]RRM1 inhibition sensitizes lung adenocarcinoma to decitabine treatment

[ 11 ]A self-amplifying USP14-TAZ loop drives the progression and liver metastasis of pancreatic ductal adenocarcinoma

[ 12 ]Acetylation of MORC2 by NAT10 regulates cell-cycle checkpoint control and resistance to DNA-damaging chemotherapy and radiotherapy in breast cancer

[ 13 ]Modulating tumor-stromal crosstalk via a redox-responsive nanomedicine for combination tumor therapy

[ 14 ]Dual stimuli-responsive dendronized prodrug derived from poly(oligo-(ethylene glycol) methacrylate)-based copolymers for enhanced anti-cancer therapeutic effect

[ 15 ]Destabilization of microrchidia family CW-type zinc finger 2 via the cyclin-dependent kinase 1-chaperone-mediated autophagy pathway promotes mitotic arrest and enhances cancer cellular sensitivity to microtubule-targeting agents

[ 16 ]Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network

[ 17 ]ROS Scavenging Nanozyme Modulates Immunosuppression for Sensitized Cancer Immunotherapy

[ 18 ]ROS Scavenging and inflammation-directed polydopamine nanoparticles regulate gut immunity and flora therapy in inflammatory bowel disease

[ 19 ]Mucin-fused myeloid-derived growth factor (MYDGF164) exhibits a prolonged serum half-life and alleviates fibrosis in chronic kidney disease

[ 20 ]Covalent targeting the LAS1-NOL9 axis for selective treatment in NPM1 mutant acute myeloid leukemia

[ 21 ]One stone with two birds: Phytic acid-capped platinum nanoparticles for targeted combination therapy of bone tumors

[ 22 ]tRF-3013b inhibits gallbladder cancer proliferation by targeting TPRG1L

[ 23 ]Tumor-derived miR-378a-3p-containing extracellular vesicles promote osteolysis by activating the Dyrk1a/Nfatc1/Angptl2 axis for bone metastasis

[ 24 ]Suppression of PARP1 Enhances PTEN mRNA Therapy in Castration-Resistant Prostate Cancer by Glycolysis Disruption

[ 25 ]BRAF-activated WT1 contributes to cancer growth and regulates autophagy and apoptosis in papillary thyroid carcinoma

[ 26 ]USP9X promotes apoptosis in cholangiocarcinoma by modulation expression of KIF1Bβ via deubiquitinating EGLN3

[ 27 ]Si-Wu-Tang ameliorates chemotherapy-induced premature ovarian insufficiency by regulating a signaling pathway in endoplasmic reticulum stress

[ 28 ]Gomisin D alleviates liver fibrosis through targeting PDGFRβ in hepatic stellate cells

[ 29 ]Biological activity reduction and mitochondrial and lysosomal dysfunction of mesenchymal stem cells aging in vitro

[ 30 ]Pt(IV) Prodrug as a Potential Antitumor Agent with APE1 Inhibitory Activity

[ 31 ]A co-delivery nanoplatform for a lignan-derived compound and perfluorocarbon tuning IL-25 secretion and the oxygen level in tumor microenvironments for meliorative tumor radiotherapy

[ 32 ]LARP6 Regulates Keloid Fibroblast Proliferation, Invasion, and Ability to Synthesize Collagen

[ 33 ]Discovery of High-Affinity Inhibitors of the BPTF Bromodomain

[ 34 ]Design, synthesis, and biological evaluation of trizole-based heteroaromatic derivatives as Bcr-Abl kinase inhibitors

[ 35 ]Design, synthesis, biological evaluation and molecular docking study of novel urea-based benzamide derivatives as potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors

[ 36 ]GSK3β rephosphorylation rescues ALPL deficiency-induced impairment of odontoblastic differentiation of DPSCs

[ 37 ]Human Adipose Mesenchymal Stem Cell-derived Exosomes Protect Mice from DSS-Induced Inflammatory Bowel Disease by Promoting Intestinal-stem-cell and Epithelial Regeneration

[ 38 ]Discovery of bipyridine amide derivatives targeting pRXRα-PLK1 interaction for anticancer therapy

[ 39 ]Structure-based discovery of novel α-aminoketone derivatives as dual p53-MDM2/MDMX inhibitors for the treatment of cancer

[ 40 ]Discovery of the GSH responsive “Y-PROTACs” targeting ALK and CDK4/6 as a potential treatment for cancer

[ 41 ]Discovery of novel benzamide derivatives bearing benzamidophenyl and phenylacetamidophenyl scaffolds as potential antitumor agents via targeting PARP-1

[ 42 ]BMSC-Derived Small Extracellular Vesicles Induce Cartilage Reconstruction of Temporomandibular Joint Osteoarthritis via Autotaxin–YAP Signaling Axis

[ 43 ]Inhibition of Growth of Colon Tumors and Proliferation of HT-29 Cells by Warburgia ugandensis Extract through Mediating G0/G1 Cell Cycle Arrest, Cell Apoptosis, and Intracellular ROS Generation

[ 44 ]Neddylation inactivation affects cell cycle and apoptosis in sheep follicular granulosa cells

[ 45 ]Discovery of penipanoid C-inspired 2-(3,4,5-trimethoxybenzoyl)quinazolin-4(3H)-one derivatives as potential anticancer agents by inhibiting cell proliferation and inducing apoptosis in hepatocellular carcinoma cells

[ 46 ]Targeting EGFR with sanguinarine chloride: a novel approach to bladder cancer therapy

[ 47 ]Stimulation of ROS Generation by Extract of Warburgia ugandensis Leading to G0/G1 Cell Cycle Arrest and Antiproliferation in A549 Cells

[ 48 ]The ETS Inhibitor YK-4-279 Suppresses Thyroid Cancer Progression Independent of TERT Promoter Mutations

[ 49 ]eIF4A1 Inhibitor Suppresses Hyperactive mTOR-Associated Tumors by Inducing Necroptosis and G2/M Arrest

[ 50 ]A novel stilbene derivative (GMQ3) suppressed proliferation and induced apoptosis in lung cancer via the p38-MAPK/SIRT1 pathway

[ 51 ]Spindle pole body component 24 homolog potentiates tumor progression via regulation of SRY-box transcription factor 2 in clear cell renal cell carcinoma

[ 52 ]C1orf112 promotes breast cancer growth by modulating the cell cycle

[ 53 ]microRNA-145-5p inhibits prostate cancer bone metastatic by modulating the epithelial-mesenchymal transition

[ 54 ]New activities of homoyessotoxin against lung cancer through the regulation of EGFR/PI3K/AKT pathway

[ 55 ]Herba Patriniae Component Linarin Induces Cell Cycle Arrest and Senescence in Non-Small-Cell Lung Cancer Associated with Cyclin A2 Downregulation

[ 56 ]Keratinocyte-derived exosomal miR-31-5p reduces vemurafenib sensitivity in melanoma cells

[ 57 ]Oroxylin A Directly Targets SRC to Inhibit the PI3K/AKT Signaling Axis in Pancreatic Cancer: An Integrated Bioinformatics and Experimental Study

[ 58 ]MAGI2-AS3 inhibits breast cancer by downregulating DNA methylation of MAGI2

[ 59 ]A lytic bacteriophage vB_KpnP-6K2 inhibits ST11-KL64 Klebsiella pneumoniae induced cell death and inflammatory response

[ 60 ]Design, semi-synthesis and bioactivity evaluation of novel podophyllotoxin derivatives as potent anti-tumor agents

[ 61 ]Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway

[ 62 ]Thermogelling chitosan-based polymers for the treatment of oral mucosa ulcers

[ 63 ]Silver Nanoparticle-Induced Apoptosis in ARPE-19 Cells Is Inhibited by Toxoplasma gondii Pre-Infection Through Suppression of NOX4-Dependent ROS Generation

[ 64 ]Membrane protein-focused CRISPR screen identifies ATP2A2 as a druggable transcriptional co-regulator of CCND1 (cyclin D1) in lung adenocarcinoma

[ 65 ]EGFR/tubulin dual-targeting podophyllotoxin triazole ester derivatives: Design, synthesis, and anti-NSCLC activity evaluation

[ 66 ]ATM Expression Is Elevated in Established Radiation-Resistant Breast Cancer Cells and Improves DNA Repair Efficiency

[ 67 ]KHSRP modulated cell proliferation and cell cycle via regulating PPP2CA and p27 expression in Wilms tumor

[ 68 ]Exploring the Antioxidant Effects and Periodic Regulation of Cancer Cells by Polyphenols Produced by the Fermentation of Grape Skin by Lactobacillus plantarum KFY02

[ 69 ]Bisphenol AP promotes pulmonary fibrosis by regulating macrophage function in a bleomycin-induced mouse model

[ 70 ]Endogenous HIV-1 Tat Promotes Cell Proliferation, Migration, and Phagocytosis in Stably Infected Macrophages by Accumulating Lactate and Activating the Autophagy/MAPK Pathway

[ 71 ]Circ_0062270 upregulates EPHA2 to facilitate melanoma progression via sponging miR-331-3p

[ 72 ]Low-Frequency Magnetic Fields (LF-MFs) Inhibit Proliferation by Triggering Apoptosis and Altering Cell Cycle Distribution in Breast Cancer Cells

[ 73 ]The m6A RNA methyltransferase METTL3/METTL14 promotes leukemogenesis through the mdm2/p53 pathway in acute myeloid leukemia

[ 74 ]GNA14 stimulation of KLF7 promotes malignant growth of endometrial cancer through upregulation of HAS2

[ 75 ]Cardiomyocyte-derived BDNF restricts cardiac fibrosis by decreasing the activity of the TGF-β/Smad2/3 pathway and increasing Smad7 expression

[ 76 ]LncRNA UNC5C-AS1 inhibits angiogenesis and induces endothelial apoptosis via the miR-148a-3p/EMP1 axis in preeclampsia

[ 77 ]Overexpression of YBX1 Promotes Pancreatic Ductal Adenocarcinoma Growth via the GSK3B/Cyclin D1/Cyclin E1 Pathway

[ 78 ]CircHIPK2 Contributes to DDP Resistance and Malignant Behaviors of DDP-Resistant Ovarian Cancer Cells Both in vitro and in vivo Through circHIPK2/miR-338-3p/CHTOP ceRNA Pathway

[ 79 ]C-Phycocyanin exerts anti-cancer effects via the MAPK signaling pathway in MDA-MB-231 cells

[ 80 ]Tribbles pseudokinase 3 (TRIB3) contributes to the progression of hepatocellular carcinoma by activating the mitogen-activated protein kinase pathway

[ 81 ]Ferredoxin reductase regulates proliferation, differentiation, cell cycle and lipogenesis but not apoptosis in SZ95 sebocytes

[ 82 ]TGFA promotes the development of cervical cancer via interacting with DSG2

[ 83 ]The Cytotoxicity Effect of Resveratrol: Cell Cycle Arrest and Induced Apoptosis of Breast Cancer 4T1 Cells

[ 84 ]Successive treatment with naltrexone induces epithelial–mesenchymal transition and facilitates the malignant biological behaviors of bladder cancer cells

[ 85 ]The hsa_circ_0000276-ceRNA regulatory network and immune infiltration in cervical cancer

[ 86 ]Identification of Selective, Cell Active Inhibitors of Protein Arginine Methyltransferase 5 through Structure-Based Virtual Screening and Biological Assays

[ 87 ]Sox9 facilitates proliferation, differentiation and lipogenesis in primary cultured human sebocytes

[ 88 ]Silkworm as a model for NAD⁺-dependent lifespan regulation: Functional insights into BmNmnat1 and nicotinic acid

[ 89 ]Induction of apoptosis in glioma cells by lycorine via reactive oxygen species generation and regulation of NF-κB pathways

[ 90 ]M1‑like tumor‑associated macrophages enhance proliferation and anti‑apoptotic ability of liver cancer cells via activating the NF‑κB signaling pathway

[ 91 ]TMEM119 links to ovarian endometriosis progression via MAPK-mediated suppression of ectopic endometrial stromal cell senescence

[ 92 ]STAT3 inhibitor BBI608 reduces patient-specific primary cell viability of cervical and endometrial cancer at a clinical-relevant concentration

[ 93 ]Effects of Nicotinamide on Cervical Cancer-Derived Fibroblasts: Evidence for Therapeutic Potential

[ 94 ]Pepsin enhances glycolysis to promote malignant transformation of vocal fold leukoplakia epithelial cells with dysplasia

[ 95 ]Grape skin fermentation by Lactobacillus fermentum CQPC04 has anti-oxidative effects on human embryonic kidney cells and apoptosis-promoting effects on human hepatoma cells

[ 96 ]Trophoblast KHSRP deficiency induces DNA damage and apoptosis via TFPI2 in unexplained spontaneous miscarriage

[ 97 ]Potential anti-inflammatory activity of walnut protein derived peptide leucine-proline-phenylalanine in lipopolysaccharides-irritated RAW264.7 cells

[ 98 ]Notoginsenoside Fc Accelerates Reendothelialization following Vascular Injury in Diabetic Rats by Promoting Endothelial Cell Autophagy

[ 99 ]Hsa_circ_001193 regulates proliferation and apoptosis of nasopharyngeal carcinoma cells through targeting mir-496

[ 100 ]Effects study of SCGB2A2 on cell proliferation and milk components biosynthesis in ovine mammary epithelial cells