eIF4A1抑制剂eFT226通过坏死性凋亡和G2/M期阻滞抑制mTOR相关肿瘤

Abstract

Aberrantly activated mechanistic target of rapamycin (mTOR) signaling pathway stimulates translation initiation/protein synthesis and eventually causes tumors. Targeting these processes thus holds potential for treating mTOR-associated diseases. We tested the potential of eFT226, a sequence-selective inhibitor of eIF4A-mediated translation, in the treatment of mTOR hyperactive cells caused by the deletion of tuberous sclerosis complex 1/2 (TSC1/2) or phosphatase and TENsin homology (PTEN). eFT226 preferentially inhibited the proliferation ofTsc2- andPten-deficient cells by inducing necroptosis and G2/M phase arrest. In addition, eFT226 blocked the development ofTSC2-deficient tumors. The translation initiation inhibitor is thus a promising regimen for the treatment of hyperactive mTOR-mediated tumors.Keywords:Tsc2;Pten;mTOR;tumor;necroptosis;eFT226