Dacomitinib（达克替尼；PF29980; PF299; PF-00299804; PF-29980; PF-299; PF00299804）是一种有效的，不可逆的泛ErbB抑制剂（pan-HER抑制剂），对EGFR、ERBB2、ERBB4的IC₅₀值分别为6 nM、45.7 nM和73.7 nM。Dacomitinib可抑制细胞生长并诱导凋亡。

参考文献

[1] Kalous O, et al. Dacomitinib (PF-00299804), an irreversible Pan-HER inhibitor, inhibits proliferation of HER2-amplified breast cancer cell lines resistant to trastuzumab and lapatinib. Mol Cancer Ther. 2012;11(9):1978-87.

[2] Engelman JA, et al. PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib. Cancer Res. 2007;67(24):11924-32.

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