Mitoxantrone dihydrochloride（又名米托蒽醌二盐酸盐, mitozantrone dihydrochloride; Mitoxantrone 2HCl; NSC-301739 dihydrochloride; NSC301739 2HCl; NSC 301739 2HCl）是拓扑异构酶II抑制剂（topoisomerase II抑制剂）和蛋白激酶C抑制剂（PKC抑制剂），对PKC的IC₅₀值为8.5 μM。Mitoxantrone通过抑制DNA合成和细胞周期进程抑制白血病，可以诱导细胞凋亡，具有抗肿瘤活性。

参考文献

[1] Takeuchi N, et al. Inhibitory effect of mitoxantrone on activity of protein kinase C and growth of HL60 cells. J Biochem. 1992 Dec;112(6):762-7.

[2] Bellosillo B, et al. Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells. Br J Haematol. 1998 Jan;100(1):142-6.

[3] Herman EH, et al. Comparison of the structural changes induced by doxorubicin and mitoxantrone in the heart, kidney and intestine and characterization of the Fe (III)-mitoxantrone complex. J Mol Cell Cardiol. 1997 Sep;29(9):2415-30.

[4] Oudard S, et al. Activity of docetaxel with or without estramustine phosphate versus mitoxantrone in androgen dependent and independent human prostate cancer xenografts. J Urol. 2003 May;169(5):1729-34.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。