Hydroxyfasudil (HA-1100, HA1100)，又称羟基法舒地尔，是fasudil hydrochloride的活性代谢物，是ATP竞争性、可逆的ROCK特异性抑制剂，作用于ROCK1/2的IC₅₀值分别为0.73 μM和0.72 μM。Hydroxyfasudil也能抑制中性粒细胞迁移，在体内表现出血管扩展剂的作用。

参考文献

1.Rikitake Y, et al. Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke. 2005 Oct;36(10):2251-7.

2.Masago T, et al. Effect of the rho-kinase inhibitor hydroxyfasudil on bladder overactivity: an experimental rat model. Int J Urol. 2009 Oct;16(10):842-7.

3.Saito M, et al. Hydroxyfasudil ameliorates penile dysfunction in the male spontaneously hypertensive rat. Pharmacol Res. 2012 Oct;66(4):325-31.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。