AG-1478 (AG148, Tyrphostin AG-1478, NSC 693255, NSC693255)是一种选择性EGFR抑制剂，抑制EGFR磷酸化以及超氧阴离子生成，IC50为3 nM，具有潜在抗肿瘤作用。AG-1478对Trk、ErbB2和PDGFR的选择性较差。AG-1478通过靶向PI4KA对脑心肌炎病毒EMCV和丙型肝炎病毒HCV表现出抗病毒活性。
参考文献
1.Bojko A, et al. The effect of tyrphostins AG494 and AG1478 on the autocrine growth regulation of A549 and DU145 cells. Folia Histochem Cytobiol. 2012 Jul 5;50(2):186-95.
2.Li W, et al. EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice. Sci Rep. 2016 Apr 18;6:24580.
3.Akhtar S, et al. Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo. PLoS One. 2015 Jul 13;10(7):e0132215.
4.Dorobantu CM, et al. Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα. Antimicrob Agents Chemother. 2016 Sep 23;60(10):6402-6.
冰袋运输。粉末直接保存于-20℃，有效期2年。建议分装后-20℃干燥保存，避免反复冻融。
