_{Sunitinib Malate是多靶点受体酪氨酸激酶(RTK)抑制剂，抑制VEGFR2和PDGFR β活性，无细胞实验中检测IC50值分别为80 nM和2 nM。Sunitinib Malate还会抑制c-Kit的活性，IC50值为211 nM。除此之外，Sunitinib Malate还是一种有效的ATP竞争性抑制剂，可通过抑制自身磷酸化和激活RNase来有效抑制Ire1α的磷酸化，达到有效抑制肿瘤细胞增殖，诱导细胞凋亡的目的。}

参考文献

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[2] O'Farrell AM, et al. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood, 2003, 101(9), 3597-3605.

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冰袋运输。粉末-20 ℃保存，3年有效；4 ℃保存，2年有效。储存液-80 ℃保存，6个月有效；-20 ℃保存，1个月有效。