LY-411575是一种高效的细胞渗透性和选择性的小分子γ分泌酶（γ-secretase）抑制剂，可抑制Notch信号通路，其IC50值为0.39 nM。LY-411575还可抑制Aβ40蛋白的产生，基于膜或细胞的IC50值分别为0.078 nM和0.082 nM。在高浓度下，LY-411575可抑制Notch信号通路，诱导肠道杯状细胞的增生和胸腺萎缩。

参考文献

[1]. Zhang J, et al. Notch signaling modulates proliferative vitreoretinopathy via regulating retinal pigment epithelial-to-mesenchymal transition. Histochem Cell Biol. 2017 Mar;147(3):367-375.

[2]. Lin HJ, et al. Gamma-Secretase Inhibitors Attenuate Neurotrauma and Neurogenic Acute Lung Injury in Rats by Rescuing the Accumulation of Hypertrophic Microglia. Cell Physiol Biochem. 2017;44(5):1726-1740.

[3]. Chen X, et al. LY411575, a potent γ-secretase inhibitor, suppresses osteoclastogenesis in vitro and LPS-induced calvarial osteolysis in vivo. J Cell Physiol. 2019 Nov;234(11):20944-20956.

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