MG132 (MG-132, Z-Leu-Leu-Leu-al, Z-Leu-Leu-Leu-CHO)是强效的、可逆的、细胞通透性proteasome抑制剂(IC50 = 100 nM)，抑制20S蛋白酶体的ZLLL-MCA降解活性时，比ZLLal有效1000多倍。MG132也可以抑制细胞周期和细胞周期蛋白降解所需要的calpain (IC50 = 1.2 μM)，并诱导PC12细胞中神经突增生。另外，MG132抑制IκBα降解，从而抑制NF-κB通路活化。MG132诱导MPM细胞凋亡，并伴随caspase 3、7、8、9蛋白活化。MG132还诱导线粒体膜电位变化，而且细胞内ROS水平也会提高。

参考文献

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粉末直接保存于-20 ºC，有效期2年。溶于DMSO，建议分装后-20ºC避光保存，避免反复冻存，至少可存放6个月。