BMS-754807是可逆的IGF-1R/IR抑制剂，IC₅₀为1.8 nM/1.7 nM，通过抑制IGF-1R的催化功能区，抑制IGF-1R和IR的活性，能抑制人类多种肿瘤细胞系的生长。

参考文献

[1] Carboni JM, Wittman M, Yang Z, et, al. BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR. Mol Cancer Ther. 2009 Dec;8(12):3341-9. doi: 10.1158/1535-7163.MCT-09-0499(IF:4.856).

[2] Kolb EA, Gorlick R, Lock R, et, al. Initial testing (stage 1) of the IGF-1 receptor inhibitor BMS-754807 by the pediatric preclinical testing program. Pediatr Blood Cancer. 2011 Apr;56(4):595-603. doi: 10.1002/pbc.22741(IF:2.486).

-25~-15℃保存，有效期3年。