PX-478 2HCl是可口服的HIF-1α的抑制剂，降低缺氧和常氧环境下各种细胞系中HIF-1α蛋白水平和HIF-1反式激活，具有抗肿瘤活性。

参考文献

[1] Welsh S, Williams R, Kirkpatrick L, et al. Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha. Mol Cancer Ther. 2004 Mar;3(3):233-44(IF:4.856).

[2] Palayoor ST, Mitchell JB, Cerna D, et al. PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells. Int J Cancer. 2008 Nov 15;123(10):2430-7. doi: 10.1002/ijc.23807(IF:4.982).

-25~-15℃保存，有效期3年。