Loganin (Loganoside),又称马钱苷、马钱子苷或马钱素,是一种从马钱子种子中分离出来的环烯醚萜苷,是非竞争性的β位淀粉样蛋白前体蛋白裂解酶1 (BACE1)非肽类抑制剂,IC50值47.97 μM,也是COX-1抑制剂;也能抑制AChE和BChE,IC50值为3.95 μM和33.02 μM,具有抗炎和抗氧化的作用。
参考文献
[1] Park KS, Kim BH, Chang IM. Inhibitory Potencies of Several Iridoids on Cyclooxygenase-1, Cyclooxygnase-2 Enzymes Activities, Tumor Necrosis factor-α and Nitric Oxide Production In Vitro. Evid Based Complement Alternat Med. 2010 Mar;7(1):41-5. doi: 10.1093/ecam/nem129(IF:1.984).
[2] Tseng YT, Chen CS, Jong YJ, et, al. Loganin possesses neuroprotective properties, restores SMN protein and activates protein synthesis positive regulator Akt/mTOR in experimental models of spinal muscular atrophy. Pharmacol Res. 2016 Sep;111:58-75. doi: 10.1016/j.phrs.2016.05.023(IF:5.574).
-25~-15℃保存,有效期3年。





