tCFA15是一种侧链含有15个碳原子的三甲基环己烯长链脂肪醇,不仅能调控Notch信号传导,还能促进神经元分化。
参考文献
[1] Gonzalez de Aguilar JL, et al. Neurotrophic activity of 2,4,4-trimethyl-3-(15-hydroxypentadecyl)-2-cyclohexen-1-one in cultured central nervous system neurons. Brain Res. 2001 Nov 30;920(1-2):65-73. doi: 10.1016/s0006-8993(01)03007-4. PMID: 11716812.
[2] Bouissac J, et al. tCFA15, a trimethyl cyclohexenonic long-chain fatty alcohol, affects neural stem fate and differentiation by modulating Notch1 activity. Eur J Pharmacol. 2013 Oct 15;718(1-3):383-92. doi: 10.1016/j.ejphar.2013.08.005. Epub 2013 Aug 24. PMID: 23978568.
[3] Girlanda-Junges C, et al. 3-(15-Hydroxypentadecyl)-2,4,4-trimethyl-2-cyclohexen-1-one and its effect on neuropeptide secretion. Bioorg Med Chem Lett. 2000 Nov 20;10(22):2537-9. doi: 10.1016/s0960-894x(00)00508-4. PMID: 11086724.
[4] Shinbori C, et al. Effects of cyclohexanonic long-chain fatty alcohol, tCFA15 on amino acids in diabetic rat brain: a preliminary study. Neurochem Res. 2008 Jul;33(7):1189-95. doi: 10.1007/s11064-008-9611-2. Epub 2008 Mar 13. PMID: 18338258.
冰袋运输。粉末直接保存于-20℃,有效期2年。建议分装后-20℃干燥保存,避免反复冻融。