Bardoxolone methyl (RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me)，又称甲基巴多索隆，是一种合成的三萜类化合物，来源于天然产物齐墩果酸，是IKK抑制剂，抑制NF-κB转录活性，也是Keap1-Nrf2途径的激活剂，具有抗炎和抗癌等作用，临床上用于治疗实体瘤、II型糖尿病和慢性肾脏疾病。

参考文献

[1] Honda T, et al. Synthetic oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophages. J Med Chem. 2000 Nov 2;43(22):4233-46.

[2] Konopleva M, et al. Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia. Blood. 2002 Jan 1;99(1):326-35.

[3] Liby K, et al. The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice. Cancer Res. 2007 Mar 15;67(6):2414-9.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。