SC-514 (GK 01140, GK01140, SC514)是可口服、ATP竞争性IKK2选择性抑制剂，IC₅₀为3-12 μM，通过与IKK-2的ATP结合位点特异性结合发挥抑制作用，阻断NF-κB依赖性基因表达，但不抑制其它IKK亚型，具有抗炎作用。

参考文献

[1] Kishore N, et al. A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts. J Biol Chem. 2003 Aug 29;278(35):32861-71.

[2] Tse AK, et al. Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition. Redox Biol. 2017 Apr;11:562-576.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。