BAY 11-7085 (BAY 11-7083)是NK-κB活化的抑制剂，不可逆地抑制TNF-α诱导的IκBα磷酸化，IC₅₀为10 μM。BAY 11-7085会促进癌细胞凋亡，可作为放疗增敏药物。

参考文献

[1] Pierce JW, et al. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesionmolecule expression show anti-inflammatory effects in vivo. J Biol Chem. 1997 Aug 22;272(34):21096-103.

[2] Nasu K, et al. Application of the nuclear factor-kappaB inhibitor BAY 11-7085 for the treatment of endometriosis: an in vitro study. Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E16-23.

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