IKK-16 (IKK Inhibitor VII)，一种可渗透细胞的苯甲酰氨基嘧啶化合物，是ATP竞争性的IκB激酶(IKK)选择性抑制剂，可抑制细胞中IκBα降解和NF-κB介导的基因表达。IKK是参与细胞炎症反应的上游NF-KB信号转导。IKK-16作用于IKK1/2和IKK complex的IC₅₀值为200 nM、40 nM和70 nM。

参考文献

1. Waelchli R, et al. Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK. Bioorg Med Chem Lett. Bioorg Med Chem Lett. 2006 Jan 1;16(1):108-12.
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