瑞沙托维Resatorvid(TAK-242/CLI-095) TLR4选择性抑制剂|CAS 243984-11-4（53767ES）

Resatorvid (TAK-242, CLI-095, TAK242, CLI095)，又称瑞沙托维，是TLR4信号的选择性抑制剂，具有抗炎活性。Resatorvid通过与TLR4胞内区域的Cys747残基直接结合，破坏TLR4与衔接子分子TIRAP和TRAM的相互作用，进而抑制TLR4信号。

参考文献：

1. Ii M, et al. A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling. Mol Pharmacol. 2006 Apr;69(4):1288-95.

2. Yamada M, et al. Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: synthesis and biological activity of alkyl 6-(N-substituted sulfamoyl)cyclohex-1-ene-1-carboxylate. J Med Chem. 2005 Nov 17;48(23):7457-67.

3. Yuko Ono, et al. TAK-242, a Specific Inhibitor of Toll-like Receptor 4 Signalling, Prevents Endotoxemia-Induced Skeletal Muscle Wasting in Mice. Sci Rep. 2020 Jan 20;10(1):694.

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