PF-04691502 (PF4691502)是一种高效的、ATP竞争性的PI3K(α/β/δ/γ)和mTOR的双重抑制剂，其对PI3Kα/β/δ/γ和mTOR的Ki值分别为1.8 nM/2.1 nM/1.6 nM/1.9 nM和16 nM。PF-04691502可诱导细胞凋亡。

参考文献

[1] Yuan J, et al. PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity. Mol Cancer Ther. 2011 Nov;10(11):2189-99.

[2] Kinross KM, et al. In vivo activity of combined PI3K/mTOR and MEK inhibition in a Kras(G12D);Pten deletion mouse model of ovarian cancer. Mol Cancer Ther. 2011 Aug;10(8):1440-9.

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