Sapanisertib（沙帕色替, MLN0128, INK 128, TAK-228）是一种有效的，选择性mTOR抑制剂（IC₅₀=1 nM），可通过作用mTOR延迟细胞周期，抑制细胞增殖，显著抑制肿瘤生长，同其它标准靶向治疗或化疗药物（如Sorafenib、Sutent和Paclitaxel）联合使用可以增强抗肿瘤活性。 

参考文献

[1] Lou, H.Z., et al., The novel mTORC1/2 dual inhibitor INK-128 suppresses survival and proliferation of primary and transformed human pancreatic cancer cells. Biochem Biophys Res Commun, 2014. 450(2): p. 973-8.

[2] Jessen K, et al. INK128 is a potent and selective TORC1/2 inhibitor with broad oral anti-tumor activity. AACR 2009 Molecular targets and cancer therapeutics meeting poster; Boston: 2009.

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