Salinomycin (Coxistac, Bio-cox, Procoxacin)，又称盐霉素，是一种从Streptomyces albus中分离的聚醚类离子载体型抗生素，抑制革兰氏阳性菌的生长，曾被用作抗球虫药，具有抗癌作用。Salinomycin通过靶向药物转运体ABC（ATP结合位点）、Wnt/β-catenin及其他CSC信号通路，在多种肿瘤中杀死癌症干细胞。

参考文献

1.Lu D, et al. Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc Natl Acad Sci USA. 2011;108(32):13253-7.

2.Zhou J, et al. Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactiveoxygen species. Toxicol Lett. 2013;222(2):139-45.

3.Wang F, et al. Salinomycin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cells In Vitro and In Vivo. PLoS One. 2012;7(12): e50638.

4.Qu H, et al. Effect of salinomycin on metastasis and invasion of bladder cancer cell line T24. Asian Pac J Trop Med. 2015 Jul;8(7):578-82.

5.Naujokat C, et al. Salinomycin as a drug for targeting human cancer stem cells. J Biomed Biotechnol. 2012;2012:950658.

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