Metformin hydrochloride（二甲双胍盐酸盐）是一种广泛使用的治疗II型糖尿病的药物，可以激活AMPK。Metformin降低血糖的作用主要是通过LKB1依赖的AMPK的活化反应实现的，Metformin抑制肝细胞中葡萄糖的产生，并刺激分离的大鼠骨骼肌中葡萄糖的摄取，而这些作用都离不开AMPK的活化反应。越来越多体内外研究表明，Metformin可以显著抑制多种癌细胞生长，如乳腺癌细胞、前列腺癌细胞、胃癌细胞和淋巴瘤等。

【该产品仅用于科研实验，不能用于人体】

参考文献
[1] Zhou G, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. 108(8):1167–1174(2001).

[2] Reuben J. Shaw, et al. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. PNAS 101(10): 3329-3335(2004).

[3] Marc Foretz, et al. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J Clin Invest. 120(7):2355–2369(2010).

[4] Qianqian Guo, et al. Metformin inhibits growth of human non-small cell lung cancer cells via liver kinase B-1-independent activation of adenosine monophosphate-activated protein kinase. Molecular Medicine Reports 13(3): 2590-2596 (2016).

[5] Alexa S. Green, et al. The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation. Blood 116: 4262-4273(2010).

客户使用本产品发表的科研文献（部分）

[1] Guo Y, et al. Hyperglycemia Induces Meibomian Gland Dysfunction. Invest Ophthalmol Vis Sci. 2022 Jan 3;63(1):30. doi: 10.1167/iovs.63.1.30. PMID: 35072689; PMCID: PMC8802017.    IF：4.799

粉末直接保存于-20 ºC，有效期2年。溶于水。建议分装后-20ºC避光保存，避免反复冻存，至少可存放6个月。