Clofarabine（氯法拉滨；克罗拉滨）是DNA合成抑制剂，抑制ribonucleotide reductase (RNR) (IC₅₀=65 nM)，也是脱氧胞苷激酶(dCK)的底物。Clofarabine抑制DNA合成并诱导细胞凋亡，具有抗癌活性。

参考文献

[1] Yamauchi T, et al. DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4-hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabine. Clin Cancer Res. 2001 Nov;7(11):3580-9. PMID: 11705880.

[2] Bonate PL, et al. Discovery and development of clofarabine: a nucleoside analogue for treating cancer. Nat Rev Drug Discov. 2006 Oct;5(10):855-63. doi: 10.1038/nrd2055. PMID: 17016426.

-25~-15℃保存，有效期3年。避光干燥保存，避免反复冻融。