K-252 (K252; K 252)是一种可从Nocardiopsis sp.中分离得到的十字孢碱的类似物，是蛋白激酶C (PKC)和蛋白激酶A (PKA)的抑制剂，具有细胞渗透性、可逆性和ATP竞争性，IC₅₀值分别为2.45 μM和25.7 μM。K-252c可诱导人慢性粒细胞白血病癌细胞凋亡，还能抑制β内酰胺酶(β-lactamase)、苹果酸脱氢酶和糜蛋白酶，其IC₅₀值分别为8 μM、8 μM和10 μM。

参考文献

[1] Hashimoto S. K-252a, a potent protein kinase inhibitor, blocks nerve growth factor-induced neurite outgrowth and changes in the phosphorylation of proteins in PC12h cells. J Cell Biol 1988,107:1531-1539. 

[2] Raychaudhuri SP, et al. K252a, a high-affinity nerve growth factor receptor blocker, improves psoriasis: an in vivo study using the severe combined immunodeficient mouse-human skin model. J Invest Dermatol 2004,122:812-819.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。