MAZ51 (MAZ-51)是可逆的VEGFR-3酪氨酸激酶选择性抑制剂，具有抗癌活性；低浓度(≤5 μM)时能特异性抑制VEGF-C/D诱导的VEGFR-3激活，而不影响VEGF-C介导的VEGFR2磷酸化。VEGFR3只在淋巴管内皮上表达，活化后诱导淋巴管生成，而MAZ51抑制VEGFR-3活性可以抑制淋巴管生成依赖性病理过程，如肿瘤转移。

参考文献

1.Kirkin V, et al. Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2. Eur J Biochem. 2001 Nov;268(21):5530-40.

2.Kirkin V, et al. MAZ51, an indolinone that inhibits endothelial cell and tumor cell growth in vitro, suppresses tumor growth in vivo. Int J Cancer. 2004 Dec 20;112(6):986-93.

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