PKA Inhibitor Fragment (6-22) amide (PKI-(6-22)-amide TFA; Protein Kinase A Inhibitor Fragment 6-22 Amid)可有效抑制cAMP依赖性蛋白激酶 A（PKA抑制剂），K_i值为2.8 nM。MDA-MB231乳腺癌细胞研究表明，PKI (6-22)酰胺的抗增殖作用与cAMP-PKA途径有关，因为它能够恢复催产素的作用。 

参考文献

[1] Glasset al (1989) Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein. J.Biol.Chem.2648802.

[2] Glasset al (1989) Protein kinase inhibitor-(6-22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine 10. J.Biol.Chem.26414579.

冰袋运输。粉末直接保存于-20℃，有效期2年。建议分装后-20℃干燥保存，避免反复冻融。