Tamoxifen (ICI 46474, (Z)-Tamoxifen, trans-Tamoxifen, ICI46474, TAM)，又称他莫昔芬、三苯氧胺或它莫西芬，是一种可口服有效的雌激素受体选择性调节剂；Tamoxifen通过增强Hsp90分子伴侣ATPase的活性活化Hsp90。Tamoxifen可用于乳腺癌治疗，对卵巢癌也有效，与其他抗癌药合用效果更好。Tamoxifen还能抑制PKC活性。

参考文献

1.Osborne CK. Tamoxifen in the treatment of breast cancer. N Engl J Med. 1998 Nov 26;339(22):1609-18.

2.Hawariah A, et al. In vitro response of human breast cancer cell lines to the growth-inhibitory effects of styrylpyrone derivative (SPD) and assessment of its antiestrogenicity. Anticancer Res. 1998 Nov-Dec;18(6A):4383-6.

3.Zheng A, et al. Tamoxifen-induced rapid death of MCF-7 breast cancer cells is mediated via extracellularly signal-regulated kinase signaling and can be abrogated by estrogen. Endocrinology. 2007 Jun;148(6):2764-77.

4.Jun Nagai, et al. Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue. Cell. 2019 May 16;177(5):1280-1292.e20.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。