NCT-501 (NCT501)是一种茶碱类的有效ALDH1A1选择性抑制剂，有抗肿瘤活性，作用hALDH1A1的IC₅₀值为40 nM，选择性超过其它ALDH同工酶和其它脱氢酶。ALDH1A1是肿瘤干细胞的标志物，可作为恶性前列腺癌的预后预测因子。

参考文献

1.Kulsum S et al. Cancer stem cell mediated acquired chemoresistance in head and neck cancer can be abrogated by Aldehydedehydrogenase 1 A1 inhibition. Mol Carcinog. 2017 Feb;56(2):694-711.

2.Yang SM, et al. Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1(ALDH1A1). J Med Chem. 2015 Aug 13;58(15):5967-5978.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。