FH535 (FH-535)是一种Wnt/β-catenin信号传导的小分子抑制剂；同时也是PPARγ/δ的双重拮抗剂，能阻碍GRIP1和β-catenin聚集。FH535在多种肿瘤中具有抗肿瘤活性。

参考文献

1.Handeli S, et al. A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities. Mol Cancer Ther. 2008 Mar;7(3):521-9.

2.Wu MY, et al. FH535 inhibited metastasis and growth of pancreatic cancer cells. Onco Targets Ther. 2015 Jul 6;8:1651-70.

3.Gedaly R, et al. Targeting the Wnt/β-catenin signaling pathway in liver cancer stem cells and hepatocellular carcinoma cell lines with FH535. PLoS One. 2014 Jun;9(6):e99272.

4.Polk WW. FH535 potentiation of cigarette smoke condensate cytotoxicity is associated with changes in β-catenin and EGR-1 signaling. Int J Toxicol. 2012 Jul;31(4):380-9.

5.Liu L, et al. FH535, a β-catenin pathway inhibitor, represses pancreatic cancer xenograft growth and angiogenesis. Oncotarget. 2016 Jul;7(30):47145-62.

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