Collagenase IV 胶原酶IV型 蛋白酶 肽链内切酶（40510ES）

[ 1 ]Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial

[ 2 ]Targeting PID1 generates oxysterols to switch macrophage cell fates for improved antitumor immunity

[ 3 ]“Artificial platelet injection system”: a plug-and-play platelet-based lysosome-targeting chimera for targeted protein degradation

[ 4 ]Engineering oral commensal nanovaccines to activate mucosal-systemic immune cascades against tumor

[ 5 ]Local macrophage dynamics–inspired engineering of time-programmed nano-vaccine scaffold for postoperative cancer immunotherapy

[ 6 ]Targeting DNA mismatch repair pathway by CRISPR nanosystem for boosting checkpoint blockade cancer immunotherapy

[ 7 ]Anti-alcoholism drug disulfiram for targeting glioma energy metabolism using BBB-penetrating delivery of fixed-dose combination

[ 8 ]Inhibition of the cancer stem cell immune checkpoint SOAT1 suppresses regulatory T cell functions through a trans-cellular 20(S)-Hydroxycholesterol-GPR132 pathway in mice

[ 9 ]An engineered linear cap-independent mRNA vaccine with intrinsic adjuvanticity induces potent anti-tumor immunity in mice

[ 10 ]Homotypic Targeted Photosensitive Nanointerferer for Tumor Cell Cycle Arrest to Boost Tumor Photoimmunotherapy

[ 11 ]Macrophage Membrane-Coated Nano-Gemcitabine Promotes Lymphocyte Infiltration and Synergizes AntiPD-L1 to Restore the Tumoricidal Function

[ 12 ]A Lung-Targeted γδ T Cell Nanovaccine Couples Pulmonary Immune Priming to Systemic Antitumor Immunity in Non-Small-Cell Lung Cancer

[ 13 ]Tuning Bacterial Morphology to Enhance Anticancer Vaccination

[ 14 ]Tailored Apoptotic Vesicle Delivery Platform for Inflammatory Regulation and Tissue Repair to Ameliorate Ischemic Stroke

[ 15 ]Near-Infrared Triggered Cascade of Antitumor Immune Responses Based on the Integrated Core–Shell Nanoparticle

[ 16 ]The m6A reader PRRC2A is essential for meiosis I completion during spermatogenesis

[ 17 ]Citraconate preserves T cell stemness and antitumor immunity

[ 18 ]Oxygen-Delivering Polyfluorocarbon Nanovehicles Improve Tumor Oxygenation and Potentiate Photodynamic-Mediated Antitumor Immunity

[ 19 ]Microvesicle-inspired oxygen-delivering nanosystem potentiates radiotherapy-mediated modulation of tumor stroma and antitumor immunity

[ 20 ]Hybrid M13 bacteriophage-based vaccine platform for personalized cancer immunotherapy

[ 21 ]Bioinspired nano-vaccine construction by antigen pre-degradation for boosting cancer personalized immunotherapy

[ 22 ]Guiding off-target nanomedicine repurposing in spleen for cancer immunotherapy

[ 23 ]Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases

[ 24 ]CEBPB-high dormant tumor cells drive immune evasion via S100A8 orchestrated tumor-associated macrophages reprogramming

[ 25 ]Targeting FAPα-positive hepatic stellate cells ameliorates the formation of pre-metastatic niche

[ 26 ]Engineered bacteria reprogram tumor microenvironment via cell senescence and neutrophil extracellular traps degradation

[ 27 ]Astragalus-derived nano-agonist potentiates chemotherapy by reducing tumor-suppressive macrophages

[ 28 ]CMTM6 maintains B cell-intrinsic membrane CD40 stability to regulate anti-tumor immunity

[ 29 ]Photothermal-driven sequential immunotherapy overcomes resistance to PARP inhibition in Brca1-deficient triple-negative breast cancer

[ 30 ]ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment

[ 31 ]A senescent tumor cell-derived nanovesicle directly primes splenic T cells to potentiate cancer radiotherapy

[ 32 ]Bacterial vesicles from intratumoral L. salivarius enhance PD-1 blockade via FPR1-mediated macrophage polarization in gastric cancer

[ 33 ]DHRS9 generates crotonyl-CoA from butyryl-CoA to epigenetically regulate STING transcription and potentiate immune activation

[ 34 ]Structure-corona-function engineering of micelles enables rapid hepatic bioactivation of clopidogrel for emergency antiplatelet therapy

[ 35 ]BMP2-induced Adam12+ Fibroblasts Dictate Wound-associated Skin Scarring and Fibrosis

[ 36 ]Docetaxel remodels prostate cancer immune microenvironment and enhances checkpoint inhibitor-based immunotherapy.

[ 37 ]Ketogenesis acts as an endogenous protective programme to restrain inflammatory macrophage activation during acute pancreatitis

[ 38 ]Imaging of fluorescent polymer dots in relation to channels and immune cells in the lymphatic system

[ 39 ]A simple self-assembly nanomicelle based on brain tumor-targeting peptide-mediated siRNA delivery for glioma immunotherapy via intranasal administration

[ 40 ]M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors

[ 41 ]Tumor-permeated bioinspired theranostic nanovehicle remodels tumor immunosuppression for cancer therapy

[ 42 ]Metabolic modulation via mTOR pathway and anti-angiogenesis remodels tumor microenvironment using PD-L1-targeting codelivery

[ 43 ]SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer

[ 44 ]Single-cell transcriptome analysis reveals the dynamics of human immune cells during early fetal skin development

[ 45 ]In vivo hepatocellular expression of interleukin-22 using penetratin-based hybrid nanoparticles as potential anti-hepatitis therapeutics

[ 46 ]Improvement and engineering of methionine γ-lyase from Pseudomonas deceptionensis based on molecular dynamics simulation and adaptive analysis for anti-tumor applications

[ 47 ]Interleukin-22 drives a metabolic adaptive reprogramming to maintain mitochondrial fitness and treat liver injury

[ 48 ]Single-cell transcriptomics reveals the ameliorative effect of gastrodin on cholestatic liver fibrosis

[ 49 ]Metabolic targeting of cancer by a ubiquinone uncompetitive inhibitor of mitochondrial complex I

[ 50 ]Development of bispecific anti-c-Met/PD-1 diabodies for the treatment of solid tumors and the effect of c-Met binding affinity on efficacy

[ 51 ]Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling

[ 52 ]Lipid metabolic reprogramming of macrophage by host APOBEC3 deficiency enhances anti-tumor immunity

[ 53 ]Nanotherapeutic macrophage-based immunotherapy for the peritoneal carcinomatosis of lung cancer

[ 54 ]SPINDOC functions as a mitotic molecular counter to coordinate spatiotemporal CENP-A assembly

[ 55 ]CKLF-like MARVEL transmembrane domain-containing superfamily 8 (CMTM8) promotes Notch signalling to maintain CD8+ T cell- and NK cell-dependent tumour immune escape

[ 56 ]RNF20 is required for male fertility through regulation of H2B ubiquitination in the Sertoli cells

[ 57 ]Construction of stable membranal CMTM6-PD-L1 full-length complex to evaluate the PD-1/PD-L1-CMTM6 interaction and develop anti-tumor anti-CMTM6 nanobody

[ 58 ]Single-cell chromatin accessibility landscape of cardiac non-myocytes identifies tissue repair program during heart regeneration

[ 59 ]Chemical Space Navigation of Nitidine Leads to the Discovery of a Novel PD-L1 Degradation Agent by Targeting CSN5 for Enhanced Antitumor Immunity

[ 60 ]Ultrafine Jujube Powder Enhances the Infiltration of Immune Cells during Anti-PD-L1 Treatment against Murine Colon Adenocarcinoma

[ 61 ]ClinASO: an open-source platform for rapid drug discovery of gapmer antisense oligonucleotides

[ 62 ]Deformable liposomal codelivery of vorinostat and simvastatin promotes antitumor responses through remodeling tumor microenvironment

[ 63 ]Irradiation combined with PD-L1−/− and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated T cell activation

[ 64 ]Synergistic photo/chemo-therapeutic liposome induced pyroptosis and anti-tumor immunity in head and neck squamous cell carcinoma

[ 65 ]A novel mRNA-based therapeutic vaccine elicits robust anti-tumor immunity against HPV-associated malignancies

[ 66 ]Human Decidual Mesenchymal Stem Cells Obtained From Early Pregnancy Improve Cardiac Revascularization Postinfarction by Activating Ornithine Metabolism

[ 67 ]Platycodin D induces neutrophil apoptosis by downregulating PD-L1 expression to inhibit breast cancer pulmonary metastasis

[ 68 ]NOD-Like Receptor Protein 3 Inflammasome-Dependent IL-1β Accelerated ConA-Induced Hepatitis

[ 69 ]IL-18 promotes pancreatic fibrosis via release of IL-4 from pancreatic stellate cells and induces macrophage M2 polarization

[ 70 ]Biostimulating Gut Microbiome with Bilberry Anthocyanin Combo to Enhance Anti-PD-L1 Efficiency against Murine Colon Cancer

[ 71 ]Inhibition of nicotinamide phosphoribosyltransferase protects against acute pancreatitis via modulating macrophage polarization and its related metabolites

[ 72 ]Sennoside A Ameliorates Myocardial Fibrosis After Myocardial Infarction by Binding to KDM4B and Regulates IRX2 Expression

[ 73 ]Dihydroquercetin ameliorated acetaminophen-induced hepatic cytotoxicity via activating JAK2/STAT3 pathway and autophagy

[ 74 ]Maturity of associating liver partition and portal vein ligation for staged hepatectomy-derived liver regeneration in a rat model

[ 75 ]Spermatogenic arrest of cattle-yak originated from aberrational transition from gonocytes to spermatogonia and aggravated at pachytene primary spermatocyte stage

[ 76 ]Effects of Hypoxia on the Growth and Development of the Fetal Ovine Hepatocytes in Primary Culture

[ 77 ]KLF4 drives aggressive RA-FLS phenotypes via HTR2A-mediated AKT/mTOR activation

[ 78 ]Bacterium-Inspired Nanoagents Armed with On-Switch of Immune Recruitment and Immune Activation

[ 79 ]Coaxial structured drug loaded dressing combined with induced stem cell differentiation for enhanced wound healing