Eplerenone作为一种口服有效的选择性醛固酮受体阻滞剂，对盐皮质激素受体表现出高度特异性拮抗作用，其半数抑制浓度（IC50）为0.081 μM。该药物在高血压、动脉粥样硬化、慢性收缩性心力衰竭及心血管疾病的研究领域具有重要应用价值。
|
英文别名 (English Synonym) |
Eplerenone |
|
中文名称 (Chinese Name) |
依普利酮 |
|
靶点 (Target) |
Mineralocorticoid Receptor |
|
通路 (Pathway) |
Others |
|
CAS号 (CAS NO.) |
107724-20-9 |
|
分子式 (Formula) |
C24H30O6 |
|
分子量 (Molecular Weight) |
414.49 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Dhillon S. Eplerenone: a review of its use in patients with chronic systolic heart failure and mild symptoms. Drugs. 2013 Sep;73(13):1451-62. doi: 10.1007/s40265-013-0098-z. PMID: 23881669. [2] Keidar S, Hayek T, Kaplan M, Pavlotzky E, Hamoud S, Coleman R, Aviram M. Effect of eplerenone, a selective aldosterone blocker, on blood pressure, serum and macrophage oxidative stress, and atherosclerosis in apolipoprotein E-deficient mice. J Cardiovasc Pharmacol. 2003 Jun;41(6):955-63. doi: 10.1097/00005344-200306000-00019. PMID: 12775976.
