[ 1 ]Leucine-tRNA-synthetase-2-expressing B cells contribute to colorectal cancer immunoevasion

[ 2 ]A logic-gated trispecific engager enhances macrophage killing of cancer cells in solid tumors

[ 3 ]Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease

[ 4 ]Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy

[ 5 ]Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1β-producing macrophages

[ 6 ]Redox rhythms promote fitness by modulating ageing-dependent reprogramming

[ 7 ]Macrophage IRX3 promotes diet-induced obesity and metabolic inflammation

[ 8 ]Cancer-associated fibroblasts suppress ferroptosis and induce gemcitabine resistance in pancreatic cancer cells by secreting exosome-derived ACSL4-targeting miRNAs

[ 9 ]The Small Molecule H89 Facilitates Mesenchymal Stem Cell-derived Extracellular Vesicle Release and Optimizes Therapeutic Efficacy in Liver Regeneration

[ 10 ]Phosphatidylserine-Externalized Erythrocyte Membrane Biointerface Redefines Endogenous Immunomodulation for Small-Diameter Vascular Grafts

[ 11 ]DNA G-quadruplex structure participates in regulation of lipid metabolism through acyl-CoA binding protein

[ 12 ]PRKN-IMMT/MIC60 axis promotes myocardial ischemia-reperfusion injury via lysosomal degradation of GPX4

[ 13 ]Targeting NAE1 suppresses osteoclastogenesis via dual regulation of ferritinophagy and ACSL3-mediated ferroptosis

[ 14 ]Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity

[ 15 ]Inhibition of the cancer stem cell immune checkpoint SOAT1 suppresses regulatory T cell functions through a trans-cellular 20(S)-Hydroxycholesterol-GPR132 pathway in mice

[ 16 ]Dynamic assembly of DNA-ceria nanocomplex in living cells generates artificial peroxisome

[ 17 ]TraB family proteins are components of ER-mitochondrial contact sites and regulate ER-mitochondrial interactions and mitophagy

[ 18 ]N6-methyladenosine modification-mediated mRNA metabolism is essential for human pancreatic lineage specification and islet organogenesis

[ 19 ]MARCH2 suppresses odontoblast differentiation by polyubiquitinating PTPRD

[ 20 ]Combinatorial Design of Fatty Acid-Incorporated Plasmid Lipid Nanoparticles Drives Dendritic Cell Hyperactivation for Enhanced Cancer Immunotherapy

[ 21 ]RNase H1C collaborates with ssDNA binding proteins WHY1/3 and recombinase RecA1 to fulfill the DNA damage repair in Arabidopsis chloroplasts

[ 22 ]Photoactivated iridium(III) complexes drive pyroptosis–necroptosis synergy for multi-network photoimmunotherapy of renal cell carcinoma

[ 23 ]μ-opioid receptor agonist facilitates circulating tumor cell formation in bladder cancer via the MOR/AKT/Slug pathway: a comprehensive study including randomized controlled trial

[ 24 ]Transition metal-enhanced immunity in Arabidopsis roots via an NLR pair

[ 25 ]Potyviruses recruit host eIF4A3 to block m6A-mediated RNA decay by steric hindrance of viral RNA methylation in plants

[ 26 ]A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice

[ 27 ]Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78–FOXM1–KIF20A pathway

[ 28 ]Heliangin acts as a covalent ligand of RPS2 that disrupts pre-rRNA metabolic processes in NPM1-mutated acute myeloid leukemia

[ 29 ]Structural repurposing of SGLT2 inhibitor empagliflozin for strengthening anti-heart failure activity with lower glycosuria

[ 30 ]Targeting SCAMP2 by a natural product auxarconjugatin B for glioblastoma therapy via restoring aspartate metabolic flux

[ 31 ]MEST inhibits ciliary sphingomyelin synthesis to promote tendon stem/progenitor cell osteochondrogenesis in traumatic heterotopic ossification

[ 32 ]Structure of the human Meckel-Gruber protein Meckelin

[ 33 ]Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2-arm mRNA Platform

[ 34 ]An Activity-Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

[ 35 ]Decoding IGLL5 Mutation-Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

[ 36 ]N4-acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

[ 37 ]Neuroprotective Effects of Time-Restricted Feeding Combined With Different Protein Sources in MPTP-Induced Parkinson's Disease Mice Model and Its Modulatory Impact on Gut Microbiota Metabolism

[ 38 ]Machine Learning-Enhanced Ultrasensitive Immuno-CRISPR Array Facilitates Early Diagnosis of Alzheimer's Disease by Detecting Multiple Plasma Biomarkers

[ 39 ]Neural Circuits between Nodose Ganglion and Pulmonary Neuroendocrine Cells Regulate Lung Inflammatory Responses

[ 40 ]Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

[ 41 ]Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

[ 42 ]PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats

[ 43 ]GPAM mediates mitochondrial dysfunction and the progression of alcoholic liver disease through lipid remodeling

[ 44 ]N6-methyladenosine RNA modification regulates cotton drought response in a Ca2+ and ABA-dependent manner

[ 45 ]Triple-modal PPy/ZIF-8 nanoparticles amplify autophagy and block autophagic flux via photothermal-ROS-zinc ion synergy for cancer therapy

[ 46 ]TOLLIP-mediated autophagic degradation pathway links the VCP-TMEM63A-DERL1 signaling axis to triple-negative breast cancer progression

[ 47 ]Bimetallic MOF-engineered 3D-printed PEEK implants orchestrate osteoregeneration via macrophage reprogramming

[ 48 ]New insights into the evolution of CAF1 family and utilization of TaCAF1Ia1 specificity to reveal the origin of the maternal progenitor for common wheat

[ 49 ]Coevolution of tandemly repeated hlips and RpaB-like transcriptional factor confers desiccation tolerance to subaerial Nostoc species

[ 50 ]Curcuma longa-derived extracellular vesicle-like particles ameliorate retinal neovascularization through HIF-1α and NRF2 signaling

[ 51 ]The mitochondrial translocation of phosphorylated EZH2 promotes PARP inhibitor resistance in BRCA1-deficient epithelial ovarian cancer

[ 52 ]The ZmRACK1–ZmCDPK7–ZmAPX1 module regulates plant antiviral immunity

[ 53 ]Circ-USP9X interacts with EIF4A3 to promote endothelial cell pyroptosis by regulating GSDMD stability in atherosclerosis

[ 54 ]TRIM26-mediated NKRF degradation drives Osimertinib resistance through SNRPD2-dependent stress granule formation in lung adenocarcinoma

[ 55 ]Macrophage Phenotype–Dependent Protein Corona Formation Governs Ligand Accessibility and Immune Clearance of Biomimetic Nanoparticles

[ 56 ]p53 and fatty acids collaborate to trigger ferroptosis via the FBXO2-FABP5 axis in colorectal cancer

[ 57 ]Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway

[ 58 ]Gut microbiota mediates the absorption of FLZ, a new drug for Parkinson's disease treatment

[ 59 ]HBx represses WDR77 to enhance HBV replication by DDB1-mediated WDR77 degradation in the liver

[ 60 ]UTP11 deficiency suppresses cancer development via nucleolar stress and ferroptosis

[ 61 ]Sublethal Exposure to Cadmium Induces Chemosensory Dysfunction in Fire Ants

[ 62 ]Bergenin, a bioactive compound from Bergenia purpurascens, ameliorates psoriasis by targeting γδT17 cells via PPARγ-mediated PROX1 ubiquitination and degradation

[ 63 ]Daphnetin alleviates influenza pneumonia by enhancing chaperone-mediated autophagy of KEAP1 through Heat shock cognate 71 kDa protein

[ 64 ]Xiao-Chai-Hu-Tang alleviates irinotecan-induced diarrhea via promoting bile acid reabsorption and decreasing focal adhesion kinase signaling revealed by metabolomics and proteomics

[ 65 ]Stabilization of MORC2 by estrogen and antiestrogens through GPER1- PRKACA-CMA pathway contributes to estrogen-induced proliferation and endocrine resistance of breast cancer cells

[ 66 ]p53 directly downregulates the expression of CDC20 to exert anti-tumor activity in mantle cell lymphoma

[ 67 ]Antitumor effect of CAR-T cells targeting transmembrane tumor necrosis factor alpha combined with PD-1 mAb on breast cancers

[ 68 ]Temperature-sensitive hydrogel loaded with DNase I alleviates epidural fibrosis in a mouse model of laminectomy

[ 69 ]Soft substrates promote direct chemical reprogramming of fibroblasts into neurons

[ 70 ]LncRNA Neat1 promotes the macrophage inflammatory response and acts as a therapeutic target in titanium particle-induced osteolysis

[ 71 ]Destabilization of microrchidia family CW-type zinc finger 2 via the cyclin-dependent kinase 1-chaperone-mediated autophagy pathway promotes mitotic arrest and enhances cancer cellular sensitivity to microtubule-targeting agents

[ 72 ]lncRNA TUG1 as a ceRNA promotes PM exposure-induced airway hyper-reactivity

[ 73 ]RUNX1 restrains STAT1-GITRL signaling to shape an immunosuppressive CRC microenvironment

[ 74 ]Targeting the PBX1–BCL2L1 axis as a therapeutic strategy in colorectal cancer

[ 75 ]Paeoniflorin prevents aberrant proliferation and differentiation of intestinal stem cells by controlling C1q release from macrophages in chronic colitis

[ 76 ]Elabela ameliorates doxorubicin-induced cardiotoxicity by promoting autophagic flux through TFEB pathway

[ 77 ]Melatonin inhibits atherosclerosis progression via galectin-3 downregulation to enhance autophagy and inhibit inflammation

[ 78 ]Untangling the co-effects of oriented nanotopography and sustained anticoagulation in a biomimetic intima on neovessel remodeling

[ 79 ]Co-delivery of luteolin and TGF-β1 plasmids with ROS-responsive virus-inspired nanoparticles for microenvironment regulation and chemo-gene therapy of intervertebral disc degeneration

[ 80 ]Targeting TBK1 attenuates ocular inflammation in uveitis by antagonizing NF-κB signaling

[ 81 ]Illuminating NAD+ Metabolism in Live Cells and In Vivo Using a Genetically Encoded Fluorescent Sensor

[ 82 ]Novel Ionizable Lipid Nanoparticles for SARS-CoV-2 Omicron mRNA Delivery

[ 83 ]Etomidate elicits anti-tumor capacity by disrupting the JAK2/STAT3 signaling pathway in hepatocellular carcinoma

[ 84 ]Chromatin complexes subunit BAP18 promotes triple-negative breast cancer progression through transcriptional activation of oncogene S100A9

[ 85 ]CircRNF144B/miR-342-3p/FBXL11 axis reduced autophagy and promoted the progression of ovarian cancer by increasing the ubiquitination of Beclin-1

[ 86 ]Biopsy-resolved cryo-EM structures of amyloid fibrils provide molecular insights into AL amyloidosis

[ 87 ]Covalent targeting the LAS1-NOL9 axis for selective treatment in NPM1 mutant acute myeloid leukemia

[ 88 ]A machine learning-based megakaryocyte identification system uncovers resident organs, markers, and functional diversity

[ 89 ]Chronic stress drives gastric cancer lymph node metastasis via NETosis through a feedforward ACh-NGF axis-mediated PKC-γ/STAT3 pathway

[ 90 ]Implantable red blood cell gel loaded with IL-33 treats intervertebral disc degeneration through the PI3K/AKT signaling pathway

[ 91 ]YTHDF1 phase separation triggers the fate transition of spermatogonial stem cells by activating the IκB-NF-κB-CCND1 axis.

[ 92 ]Perioperative administration of fucoidan induced changes in immune cell composition and resulted in no beneficiary outcomes in the acute phase of postoperative neurocognitive recovery

[ 93 ]A synonymous mutation in PI4KA impacts the transcription and translation process of gene expression.

[ 94 ]Targeted demethylation at ZNF154 promotor upregulates ZNF154 expression and inhibits the proliferation and migration of Esophageal Squamous Carcinoma cells

[ 95 ]Intestinal epithelial protection and gut microbiota modulation by Ganoderma lucidum proteoglycan are associated with its hypoglycemic potential in type 2 diabetes

[ 96 ]A rapid on-site diagnostic method for goose parvovirus disease based on recombinase polymerase amplification and CRISPR/AsCas12a

[ 97 ]Discrete functional and mechanistic roles of chromodomain Y-like 2 (CDYL2) transcript variants in breast cancer growth and metastasis

[ 98 ]Mussel-inspired conductive Ti2C-cryogel promotes functional maturation of cardiomyocytes and enhances repair of myocardial infarction

[ 99 ]ATP-activated decrosslinking and charge-reversal vectors for siRNA delivery and cancer therapy

[ 100 ]Mussel-inspired conductive nanofibrous membranes repair myocardial infarction by enhancing cardiac function and revascularization